Krotkiewski M, Lithell H, Shono N, Wysocki M, Holm G
Department of Rehabilitation Medicine, Sahlgrenska Hospital, Gothenburg University, Sweden.
Clin Physiol. 1998 May;18(3):203-13. doi: 10.1046/j.1365-2281.1998.00094.x.
As muscle tissue constitutes a main target organ for glucose metabolism and is responsible for the development of insulin resistance, it seems plausible to elucidate the relationship between blood pressure and muscle morphology and metabolism. The association between blood pressure and capillarization/morphology of the vastus lateralis muscle and metabolic variables was evaluated in 24 perimenopausal obese women [body mass index (BMI) 34.9 +/- 1.1; waist-hip ratio (WHR) 0.90 +/- 0.02]. The muscle enzyme activity of lipoprotein lipase (LPL), citrate synthase and glycogen synthase was determined. There was a significant negative correlation between the percentage of type I fibres and relative fibre area of type I on the one hand and systolic and diastolic blood pressure on the other. There was a negative correlation between the capillary density (i.e. number of capillaries/muscle fibre) and a positive correlation between the diffusion distance (fibre area supplied by one capillary) and diastolic blood pressure. The activities of LPL and citrate synthase were positively correlated with the percentage of type I and negatively correlated with the percentage of type II muscle fibres. The activity of LPL was also negatively correlated with plasma glucose and the insulin/C-peptide ratio. The insulin/C-peptide ratio was positively correlated with the percentage of type II muscle fibres. In stepwise multiple regression analyses, 20-30% of the variation in systolic and diastolic blood pressure could be explained by the variables of muscle fibre distribution. Excluding muscle morphological variables from the regression model, the insulin/C-peptide ratio accounted for 13% of the variation in systolic and diastolic blood pressure. The results of the study show the close association between muscle morphology and blood pressure. It remains to be elucidated whether this association indicates a causal relationship.
由于肌肉组织是葡萄糖代谢的主要靶器官，并与胰岛素抵抗的发生有关，因此阐明血压与肌肉形态和代谢之间的关系似乎是合理的。我们评估了24名围绝经期肥胖女性[体重指数（BMI）34.9±1.1；腰臀比（WHR）0.90±0.02]的血压与股外侧肌毛细血管化/形态以及代谢变量之间的关联。测定了脂蛋白脂肪酶（LPL）、柠檬酸合酶和糖原合酶的肌肉酶活性。一方面，I型纤维百分比和I型纤维相对面积与收缩压和舒张压之间存在显著负相关。毛细血管密度（即每根肌纤维的毛细血管数量）与舒张压呈负相关，扩散距离（一根毛细血管供应的纤维面积）与舒张压呈正相关。LPL和柠檬酸合酶的活性与I型纤维百分比呈正相关，与II型肌纤维百分比呈负相关。LPL的活性也与血浆葡萄糖和胰岛素/C肽比值呈负相关。胰岛素/C肽比值与II型肌纤维百分比呈正相关。在逐步多元回归分析中，收缩压和舒张压变化的20%-30%可由肌纤维分布变量解释。从回归模型中排除肌肉形态学变量后，胰岛素/C肽比值占收缩压和舒张压变化的13%。研究结果表明肌肉形态与血压之间存在密切关联。这种关联是否表明因果关系仍有待阐明。
