Frati Munari A C, Benítez Pinto W, Raúl Ariza Andraca C, Casarrubias M
Departamento de Medicina Interna, Hospital de Especialidades, México, D.F.
Arch Med Res. 1998 Summer;29(2):137-41.
A study was designed to evaluate the effect of acarbose and Plantago psyllium mucilage on glycemic index (GI) of bread.
Twelve patients with non-insulin-dependent diabetes mellitus (NIDDM) and ten healthy volunteers were studied. Three meal tests with an intake of 90 g of white bread (50 g of carbohydrates) were performed on each subject. In one test, 200 mg of acarbose was given, while 15 g of P. psyllium mucilage was given in another test, and only bread was ingested in the control test. Serum glucose and insulin concentrations were measured every 30 min from 0-180 min. Net area under curve (AUC) concentrations of glucose and insulin, GI and insulinic index were calculated.
In NIDDM patients, AUC-glucose in the test with acarbose (1.9 +/- 0.7 mmol/L) and with P. psyllium (4.3 +/- 1.2 mmol/L) were significantly lower than in the control test (7.4 +/- 1.5 mmol/L) (p < 0.01). GI of bread plus acarbose was 26 +/- 13, and of bread plus P. psyllium, 59 +/- 10 (p < 0.05). AUC-insulin and insulinic index behave similarly. In healthy individuals, AUC-glucose and GI did not significantly change with the treatments; however, insulinic index with acarbose was 17 +/- 16, and with P. psyllium was 68 +/- 15 (p < 0.05). Acarbose or P. psyllium decreased GI of bread in NIDDM patients and diminished insulinic index in NIDDM and in healthy subjects.
Adding acarbose or P. psyllium to meals may reduce glycemic index of carbohydrate foods and may help diabetic control.
设计一项研究以评估阿卡波糖和洋车前子黏液对面包血糖指数（GI）的影响。
对12名非胰岛素依赖型糖尿病（NIDDM）患者和10名健康志愿者进行研究。对每位受试者进行三次进食测试，每次摄入90克白面包（50克碳水化合物）。在一次测试中给予200毫克阿卡波糖，在另一次测试中给予15克洋车前子黏液，而在对照测试中仅食用面包。从0至180分钟，每隔30分钟测量血清葡萄糖和胰岛素浓度。计算葡萄糖和胰岛素的曲线下净面积（AUC）浓度、血糖指数和胰岛素指数。
在NIDDM患者中，服用阿卡波糖测试（1.9±0.7毫摩尔/升）和服用洋车前子测试（4.3±1.2毫摩尔/升）中的AUC-葡萄糖显著低于对照测试（7.4±1.5毫摩尔/升）（p<0.01）。面包加阿卡波糖的血糖指数为26±13，面包加洋车前子的血糖指数为59±10（p<0.05）。AUC-胰岛素和胰岛素指数表现相似。在健康个体中，治疗后AUC-葡萄糖和血糖指数无显著变化；然而，服用阿卡波糖的胰岛素指数为17±16，服用洋车前子的胰岛素指数为68±15（p<0.05）。阿卡波糖或洋车前子降低了NIDDM患者面包的血糖指数，并降低了NIDDM患者和健康受试者的胰岛素指数。
进餐时添加阿卡波糖或洋车前子可能会降低碳水化合物食物的血糖指数，并有助于控制糖尿病。
