Barrera Ferrer S M, Villalobos Cabrera H D
Instituto para el Control y la Conservación de la Cuenca del Lago de Maracaibo, Gerencia de Ecología Humana, Venezuela.
Invest Clin. 1998 Apr;39 Suppl 1:123-37.
This study presents the analysis of chemically induced somatic mutation in Drosophila larvae assayed later as single light (LS) mosaic spots in the adult eye. The larvae were treated with Vanadyl sulphate (VOSO4), the highest exposure was 10.0, 8.0, 6.0 and 4.0 mM which was the acutely lethal concentration, while than lowest exposure of 2.5, 2.0 and 1.0 mM, cause reproductive effects and genotoxic activity, compared to the control. Previous to the realization of the mutagenicity assay was determined the lethal toxicity of the compound undertest since the concentration-mortality relationship is a useful indicator of the biological activity of Vanadium. The toxic effect in fly adult was to compare any differences in the sensitivity of males (white) and female (oregon), observing the higher sensitivity of the males. The date presented with tests SMART and their statistical evaluation lead to the following conclusions. To test the two hypotheses was propose to apply the conditional binomial test (Kastenbaum and Bowman, 1970) or the X2 test for proportions (K. Pearson criterion). Each hypothesis was tested at the 5% significance level. In conclusion the Vanadyl Sulphate produce aberrant red sector in w+/w, it is not correlated with the capacity of an agent to induce chromosomal damage and mitotic recombination, but rather seems positively correlated with its weak capacity to produce points mutations.
