van Echten J, van Doorn L C, van der Linden H C, van der Veen A Y, Burger C W, de Jong B
Department of Medical Genetics, University of Groningen, The Netherlands.
Int J Cancer. 1998 Jul 17;77(2):217-8. doi: 10.1002/(sici)1097-0215(19980717)77:2<217::aid-ijc8>3.0.co;2-t.
Cytogenetic investigation of a malignant ovarian tumor diagnosed as a mixed germ-cell tumor, composed of extensive choriocarcinoma and foci of yolk-sac tumor, revealed a highly abnormal chromosomal pattern. We found a chromosome number in the hypertriploid/hypotetraploid range, and several clonal structural abnormalities, including 2 copies of an isochromosome 12p. We showed that the chromosomal pattern of this ovarian tumor is very similar to that of testicular germ-cell tumors. This finding, together with reported cytogenetic data of malignant ovarian germ-cell tumors, supports the hypothesis that ovarian and testicular germ-cell tumors are strongly related entities that may have a similar origin and pathogenetic pathway.
对一例被诊断为混合性生殖细胞肿瘤的恶性卵巢肿瘤进行细胞遗传学研究，该肿瘤由广泛的绒毛膜癌和卵黄囊瘤灶组成，结果显示出高度异常的染色体模式。我们发现染色体数目处于超三倍体/亚四倍体范围内，并且存在几种克隆性结构异常，包括2条等臂染色体12p的拷贝。我们表明，这种卵巢肿瘤的染色体模式与睾丸生殖细胞肿瘤的染色体模式非常相似。这一发现，连同已报道的恶性卵巢生殖细胞肿瘤的细胞遗传学数据，支持了卵巢和睾丸生殖细胞肿瘤是密切相关的实体，可能具有相似起源和发病机制途径的假说。
