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捷克共和国产山梨醇发酵志贺毒素（维罗毒素）的大肠杆菌O157:H-菌株的分离与特性研究

Isolation and characterization of sorbitol-fermenting Shiga toxin (Verocytotoxin)-producing Escherichia coli O157:H- strains in the Czech Republic.

作者信息

Bielaszewska M, Schmidt H, Karmali M A, Khakhria R, Janda J, Bláhová K, Karch H

机构信息

Institute of Medical Microbiology, The 2nd Medical Faculty, Charles University, Prague, Czech Republic.

出版信息

J Clin Microbiol. 1998 Jul;36(7):2135-7. doi: 10.1128/JCM.36.7.2135-2137.1998.

DOI:10.1128/JCM.36.7.2135-2137.1998
PMID:9650984
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC105006/
Abstract

Two sorbitol-fermenting (SF) Shiga toxin-producing Escherichia coli (STEC) O157:H- strains were isolated from patients with hemolytic-uremic syndrome in the Czech Republic in 1995. Their phenotypic and genotypic characteristics and genomic DNA fingerprints were identical or closely related to those of SF STEC O157:H- strains isolated in Germany in 1988 to 1997. This indicates that the Czech isolates belong to the SF STEC O157 clone which is widespread in Germany. It is the first finding of the clone outside Germany.

摘要

1995年，在捷克共和国，从溶血尿毒综合征患者中分离出两株产志贺毒素的山梨醇发酵型（SF）大肠杆菌O157:H-菌株。它们的表型、基因型特征及基因组DNA指纹图谱与1988年至1997年在德国分离出的SF STEC O157:H-菌株相同或密切相关。这表明捷克分离株属于在德国广泛传播的SF STEC O157克隆。这是该克隆在德国境外的首次发现。

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本文引用的文献

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Isolation of enterohemorrhagic Escherichia coli O157 strains from patients with hemolytic-uremic syndrome by using immunomagnetic separation, DNA-based methods, and direct culture.通过免疫磁珠分离法、基于DNA的方法和直接培养法从溶血尿毒综合征患者中分离肠出血性大肠杆菌O157菌株。
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Variants of Shiga-like toxin II constitute a major toxin component in Escherichia coli O157 strains from patients with haemolytic uraemic syndrome.志贺样毒素II的变体是溶血性尿毒症综合征患者来源的大肠杆菌O157菌株中的主要毒素成分。
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Two toxin-converting phages from Escherichia coli O157:H7 strain 933 encode antigenically distinct toxins with similar biologic activities.来自大肠杆菌O157:H7菌株933的两种毒素转换噬菌体编码具有相似生物学活性但抗原性不同的毒素。
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Close association of verotoxin (Shiga-like toxin) production with enterohemolysin production in strains of Escherichia coli.
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