Ceriani T, Colli Franzone P, Stefanelli M, Viganotti C
Int J Biomed Comput. 1976 Jul;7(3):213-34. doi: 10.1016/0020-7101(76)90028-3.
Optimisation problems arising in the identification of kinetic parameters of intestinal membranes are here considered. The dynamic behaviour of the membrane is described by means of a linear compartmental model. Using optimisation techniques of a gradient type, the intestinal kinetic parameters are identified, minimising a quadratic criterion between experimental data of D-histidine transport and model prediction. Numerical results are reported and their physiological implications discussed. The quantitative assessment of the asymmetry of diffusion constants with respect to diffusion direction seems to be an important result of this work.
本文考虑了在确定肠膜动力学参数过程中出现的优化问题。膜的动态行为通过线性房室模型来描述。利用梯度类型的优化技术，确定肠动力学参数，使D-组氨酸转运的实验数据与模型预测之间的二次准则最小化。报告了数值结果并讨论了其生理意义。关于扩散常数相对于扩散方向的不对称性的定量评估似乎是这项工作的一个重要结果。
