Boyer C, Schikorski T, Stevens C F
Molecular Neurobiology Laboratory, and Howard Hughes Medical Institute at The Salk Institute, La Jolla, California 92037, USA.
J Neurosci. 1998 Jul 15;18(14):5294-300. doi: 10.1523/JNEUROSCI.18-14-05294.1998.
We have quantified hippocampal spine structure at the light and ultrastructural levels in cell cultures approximately 1- 3 weeks old and in the brains of rodents 5 and 21 d old. The number of spines bearing synapses increases with age in cultures and in brain, but the structures are similar in both. In culture, about half of the synapses are formed on spines and the remainder are formed on dendritic shafts. In the 5-d-old brain, about half of the synapses occur on dendritic shafts, by 3 weeks of age only approximately 20% of synapses are found on dendritic shafts, and in the adult shaft synapses are very rare.
我们已在光镜和超微结构水平上，对约1至3周龄的细胞培养物以及5日龄和21日龄啮齿动物大脑中的海马棘结构进行了量化。在培养物和大脑中，带有突触的棘的数量均随年龄增长而增加，但二者的结构相似。在培养物中，约一半的突触形成于棘上，其余的则形成于树突干上。在5日龄的大脑中，约一半的突触出现在树突干上；到3周龄时，只有约20%的突触位于树突干上；而在成体中，树突干突触非常罕见。
