Gérin M, Siemiatycki J, Désy M, Krewski D
Départment de médecine du travail et d'hygiène du milieu, Université de Montréal, Québec, Canada.
Am J Ind Med. 1998 Aug;34(2):144-56. doi: 10.1002/(sici)1097-0274(199808)34:2<144::aid-ajim7>3.0.co;2-x.
Except for the leukemogenic effects of benzene, there is inadequate or sparse evidence on the carcinogenicity of the most common monocyclic aromatic hydrocarbons. The purpose of this study was to generate hypotheses on associations between exposure to benzene, toluene, xylene, and styrene and various common types of cancer.
In the context of a population-based case-control study carried out in Montreal, 3,730 cancer patients (15 types of cancers, not including leukemia) and 533 population controls were interviewed, and their job histories were translated by a team of experts into occupational exposures, including benzene, toluene, xylene, and styrene. In the present analysis, exposure to these substances was compared between each case series and a control group pooling selected cancer patients and population controls, using logistic regression analysis.
Exposure levels were low for most exposed subjects, and there was a high correlation between exposure to benzene, toluene and xylene. For most sites of cancer there was no evidence of excess risk due to these substances. However, limited evidence of increased risk was found for the following associations: esophagus-toluene, colon-xylene, rectum-toluene, rectum-xylene and rectum-styrene.
These latter observations warrant further investigation.
除苯的致白血病作用外，关于最常见的单环芳烃的致癌性证据不足或稀少。本研究的目的是提出关于接触苯、甲苯、二甲苯和苯乙烯与各种常见癌症类型之间关联的假设。
在蒙特利尔开展的一项基于人群的病例对照研究中，对3730名癌症患者（15种癌症类型，不包括白血病）和533名人群对照进行了访谈，一组专家将他们的工作经历转化为职业暴露情况，包括苯、甲苯、二甲苯和苯乙烯。在本分析中，使用逻辑回归分析，比较了每个病例系列与一个合并选定癌症患者和人群对照的对照组之间对这些物质的暴露情况。
大多数暴露受试者的暴露水平较低，苯、甲苯和二甲苯的暴露之间存在高度相关性。对于大多数癌症部位，没有证据表明这些物质会导致额外风险。然而，发现以下关联存在有限的风险增加证据：食管癌 - 甲苯、结肠癌 - 二甲苯、直肠癌 - 甲苯、直肠癌 - 二甲苯和直肠癌 - 苯乙烯。
后述观察结果值得进一步研究。
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