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杂合酶:操控酶的设计

Hybrid enzymes: manipulating enzyme design.

作者信息

Nixon A E, Ostermeier M, Benkovic S J

机构信息

Department of Chemistry, Pennsylvania State University, University Park 16802-6300, USA.

出版信息

Trends Biotechnol. 1998 Jun;16(6):258-64. doi: 10.1016/s0167-7799(98)01204-9.

Abstract

Hybrid enzymes are engineered to contain elements of two or more enzymes. Hybrid-enzyme approaches, by taking advantage of the vast array of enzymatic properties that nature has evolved, as well as the strategies that nature has used to evolve them, are becoming an increasingly important avenue for obtaining novel enzymes with desired activities and properties.

摘要

杂合酶经过工程改造,含有两种或更多种酶的成分。杂合酶方法利用了自然界进化出的大量酶特性以及自然界用于进化这些酶的策略,正日益成为获得具有所需活性和特性的新型酶的重要途径。

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