Lim H L, Teo C P, Wong K, Kueh Y K
Department of Medicine, National University Hospital, Singapore.
Singapore Med J. 1998 Feb;39(2):76-8.
A 20-year-old national serviceman with acute lymphoblastic leukaemia, developed a large left parieto-occipital haemorrhage 7 days after completion of induction chemotherapy. Severe hypofibrinogenemia had been noted while he was receiving L-asparaginase. The haemorrhage could not be attributed to thrombocytopenia, disseminated intravascular coagulopathy, arterio-venous malformation, berry aneurysm or leukaemic infiltration because each of these causes was carefully investigated into and excluded. We conclude that the intracranial haemorrhage was likely L-asparaginase induced, an uncommon but recognised complication associated with L-asparaginase therapy.
一名20岁的急性淋巴细胞白血病国家军人在诱导化疗结束7天后，发生了左侧顶枕部大面积出血。在接受L-天冬酰胺酶治疗时，发现有严重的纤维蛋白原血症。出血不能归因于血小板减少、弥散性血管内凝血、动静脉畸形、浆果状动脉瘤或白血病浸润，因为对这些病因都进行了仔细调查并排除。我们得出结论，颅内出血很可能是由L-天冬酰胺酶引起的，这是一种与L-天冬酰胺酶治疗相关的罕见但已被认识到的并发症。
