Whitelaw W A, Derenne J P, Couture J, Milic-Emili J
J Appl Physiol. 1976 Sep;41(3):285-91. doi: 10.1152/jappl.1976.41.3.285.
Normal men anesthetized with methoxyflurane rebreathed carbon dioxide under two conditions. In one case they breathed most of the time through a low-resistance circuit and an inspiratory resistor of 40.4 cmH2O/1-s-1 was applied at intervals. In another case they breathed most of the time through the resistor and were allowed occasional free breaths. There were no differences between the two types of runs in tidal volume, respiratory frequency, duration of inspiration of loaded or unloaded breaths, or in amplitude or shape of occlusion pressure waves. It is concluded that the reaction of conscious men to an inspiratory resistive load, consisting of a compensatory augmentation of neural drive to respiratory muscles that does not depend on a chemical stimulus, is absent in anesthetized men.
正常男性在甲氧氟烷麻醉下于两种条件下进行二氧化碳再呼吸。一种情况是，他们大部分时间通过低阻力回路呼吸，每隔一段时间施加一个40.4厘米水柱/秒的吸气阻力器。另一种情况是，他们大部分时间通过阻力器呼吸，偶尔允许自由呼吸。在潮气量、呼吸频率、有负荷或无负荷呼吸的吸气持续时间，或阻塞压力波的幅度或形状方面，两种类型的试验之间没有差异。得出的结论是，有意识的男性对吸气阻力负荷的反应，即对呼吸肌神经驱动的代偿性增强且不依赖于化学刺激，在麻醉的男性中不存在。
