Sahebjami H, Vassallo C L
J Appl Physiol. 1976 Sep;41(3):332-5. doi: 10.1152/jappl.1976.41.3.332.
Rats were exposed to an aerosol of 10% papain for 8 h found in pilot studies to produce marked emphysema. One week after exposure some animals were forced to exercise in a motor-driven activity wheel 2 h daily for 4 wk, while others remained at rest. Another group of rats which served as the control were exposed to saline under the same conditions and divided into exercise and rest groups. Elastic recoil pressure (Pst) of lung was measured from static deflation pressure-volume curves with air and saline. Pst measured in air-filled lungs was not significantly different between the emphysema-rest and emphysema-exercise groups. When inflated with saline the Pst was significantly reduced in the emphysema-exercise compared to the emphysema-rest group at high and mid (100, 80, 60%) lung volumes. Pst in air- and saline-filled lungs was not significantly different between the control-rest and control-exercise groups. We therefore conclude that mechanical stress resulting from physical exercise decreased Pst of lung tissue in emphysematous rats.
在前期研究中发现，将大鼠暴露于10%木瓜蛋白酶气雾剂中8小时可导致明显的肺气肿。暴露一周后，一些动物被迫在电动活动轮中每天锻炼2小时，持续4周，而其他动物则保持静止。另一组作为对照的大鼠在相同条件下暴露于盐水中，并分为运动组和静止组。通过空气和盐水的静态放气压力-容积曲线测量肺的弹性回缩压力（Pst）。在肺气肿静止组和肺气肿运动组之间，充气肺中测量的Pst没有显著差异。当用盐水充气时，与肺气肿静止组相比，在高肺容积和中肺容积（100%、80%、60%）时，肺气肿运动组的Pst显著降低。对照静止组和对照运动组之间，充气肺和充盐水肺中的Pst没有显著差异。因此，我们得出结论，体育锻炼产生的机械应力降低了肺气肿大鼠肺组织的Pst。
