Hogg J C, Nepszy S J, Macklem P T, Thurlbeck W M
J Clin Invest. 1969 Jul;48(7):1306-12. doi: 10.1172/JCI106097.
Bronchograms were performed using finely particulate lead on emphysematous lungs obtained at necropsy. X-ray films were taken of these lungs at distending pressures of 0, 5, 10, and 20 cm H(2)O. The volumes of individual centrilobular emphysematous spaces were calculated at each distending pressure from measurements made on these bronchograms and pressure-volume curves were constructed for each space. The pressure-volume characteristics of seven normal lungs and one lung with centrilobular emphysema was also measured. The normal lungs, the lung with centrilobular emphysema, and the centrilobular emphysematous spaces were compared by expressing the volume of air contained in them at each distending pressure as a per cent of the volume contained at 20 cm H(2)O distending pressure. We conclude that centrilobular emphysematous spaces have a high residual volume, are less compliant than normal lung tissue, and are much less compliant than the emphysematous lungs which contain them. Furthermore, these spaces undergo little volume change in the tidal breathing range and probably add a relatively nondistensible series dead space to the surrounding lung parenchyma.
在尸检获得的肺气肿肺上，使用细颗粒铅进行支气管造影。在0、5、10和20厘米水柱的扩张压力下，对这些肺进行X线摄影。根据这些支气管造影的测量结果，计算每个扩张压力下单个小叶中心型肺气肿腔隙的容积，并为每个腔隙构建压力-容积曲线。还测量了7个正常肺和1个小叶中心型肺气肿肺的压力-容积特性。通过将每个扩张压力下它们所含空气的容积表示为20厘米水柱扩张压力下所含容积的百分比，对正常肺、小叶中心型肺气肿肺和小叶中心型肺气肿腔隙进行比较。我们得出结论，小叶中心型肺气肿腔隙具有高残气量，比正常肺组织顺应性低，且比包含它们的肺气肿肺顺应性低得多。此外，这些腔隙在潮气量呼吸范围内容积变化很小，可能会给周围肺实质增加一个相对不可扩张的串联死腔。
