CC趋化因子6Ckine与CXC趋化因子受体CXCR3结合。
The CC chemokine 6Ckine binds the CXC chemokine receptor CXCR3.
作者信息
Soto H, Wang W, Strieter R M, Copeland N G, Gilbert D J, Jenkins N A, Hedrick J, Zlotnik A
机构信息
DNAX Research Institute for Cellular and Molecular Biology, Palo Alto, CA 94304, USA.
出版信息
Proc Natl Acad Sci U S A. 1998 Jul 7;95(14):8205-10. doi: 10.1073/pnas.95.14.8205.
Abstract
We cloned the mouse homologue of the chemokine receptor CXCR3, which is located in mouse chromosome X. We screened a large panel of chemokines for their ability to induce a calcium flux in mouse CXCR3-transfected cells and identified a new ligand for this receptor, the recently reported CC chemokine 6Ckine. This represents an example of a CC chemokine, which binds to a CXC chemokine receptor. Like other ligands of this receptor, 6Ckine has angiostatic properties. 6Ckine is known to chemoattract T cells. In line with this, CXCR3 is expressed preferentially in Th1 cells and in lymphoid organs of the IL-10(-/-) mouse that develops chronic colitis. Its ability to attract T cells as well as its angiostatic properties suggest that 6Ckine may be an effective anti-tumor agent.
摘要
我们克隆了趋化因子受体CXCR3的小鼠同源物，它位于小鼠X染色体上。我们筛选了一大组趋化因子，以检测它们在小鼠CXCR3转染细胞中诱导钙流的能力，并鉴定出该受体的一种新配体，即最近报道的CC趋化因子6Ckine。这代表了一种CC趋化因子与CXC趋化因子受体结合的例子。与该受体的其他配体一样，6Ckine具有血管生成抑制特性。已知6Ckine可趋化T细胞。与此一致的是，CXCR3优先表达于发生慢性结肠炎的IL-10(-/-)小鼠的Th1细胞和淋巴器官中。其吸引T细胞的能力及其血管生成抑制特性表明，6Ckine可能是一种有效的抗肿瘤药物。
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