Mol B W, Meijer S, Yuppa S, Tan E, de Vries J, Bossuyt P M, van der Veen F
Department of Clinical Epidemiology and Biostatistics, Academic Medical Center, University of Amsterdam, The Netherlands.
J Reprod Med. 1998 Jun;43(6):503-8.
To determine if the performance of the sperm penetration assay (SPA) is useful in predicting successful in vitro fertilization (IVF).
A meta-analysis was set up to determine the performance of SPA in the prediction of IVF success. We collected data on 647 patients in 24 studies. For each study, a two-by-two table was constructed from the results of SPA and IVF.
The sensitivity and specificity of SPA as compared to IVF were heterogeneous. A summary receiver operating characteristics curve could be estimated, showing that the sensitivity of SPA was only 37%, with a specificity of 95%. Subgroup analysis did not explain the lack of homogeneity.
Since withholding IVF inappropriately has major consequences, performing SPA is insufficient for selecting patients for treatment with IVF-embryo transfer.
确定精子穿透试验（SPA）的表现是否有助于预测体外受精（IVF）的成功。
进行一项荟萃分析以确定SPA在预测IVF成功方面的表现。我们收集了24项研究中647例患者的数据。对于每项研究，根据SPA和IVF的结果构建一个二乘二列联表。
与IVF相比，SPA的敏感性和特异性存在异质性。可以估计出一条汇总的受试者工作特征曲线，显示SPA的敏感性仅为37%，特异性为95%。亚组分析无法解释缺乏同质性的原因。
由于不恰当地取消IVF会产生重大后果，因此进行SPA不足以筛选接受IVF-胚胎移植治疗的患者。
