Harris W A, Perron M
Department of Anatomy, University of Cambridge, United Kingdom.
Int J Dev Biol. 1998;42(3):299-304.
In postembryonic lower vertebrates, the ciliary marginal zone (CMZ) of the retina is a continuously growing zone in the central nervous system. By studying the cellular and molecular biology of the cells in this region, we have discovered that the CMZ can be divided into several zones, from peripheral to central, which reflect different stages of development of retinal stem cells. Based on the behavior of the cells and on the genes expressed in different regions, we propose here that cellular development in the CMZ recapitulates in space what happens in embryonic retinal development in time.
在胚胎后期的低等脊椎动物中，视网膜的睫状边缘区（CMZ）是中枢神经系统中一个持续生长的区域。通过研究该区域细胞的细胞生物学和分子生物学，我们发现CMZ可从外周到中央分为几个区域，这些区域反映了视网膜干细胞不同的发育阶段。基于细胞的行为以及在不同区域表达的基因，我们在此提出，CMZ中的细胞发育在空间上重演了胚胎视网膜发育在时间上所发生的过程。
