Carroll S B
Howard Hughes Medical Institute and Laboratory of Molecular Biology, University of Wisconsin, Madison 53706, USA.
Int J Dev Biol. 1998;42(3):305-9.
Our understanding of animal development has been revolutionized by genetic approaches to the identification and isolation of pattern-regulating genes. In the past several years, fundamental embryological concepts such as morphogenetic fields, compartments, and organizers have been defined at a molecular level and visualized in developing animals. Here, I will discuss how the focus on the regulation and function of genes with dramatic effects on pattern formation, primarily by through the analysis of gene expression patterns as surrogates of physical pattern elements, has elucidated gene hierarchies that control developmental pathways.
通过基因方法来识别和分离调控模式的基因，我们对动物发育的理解发生了革命性的变化。在过去几年里，诸如形态发生场、区室和组织者等基本胚胎学概念已在分子水平上得到定义，并在发育中的动物体内得以可视化。在此，我将探讨，主要通过分析作为物理模式元素替代物的基因表达模式，对模式形成具有显著影响的基因的调控和功能研究如何阐明了控制发育途径的基因层级关系。
