Complete response of a primary cutaneous T-cell-rich B cell lymphoma treated with interferon alpha2a.

Primary B cell lymphomas of the skin are rare disorders and therapy is not yet standardized. A 45-year-old male patient presented 4 years after surgical removal of a subcutaneous tumour of the leg. On examination a reddish nodular tumour was found in the same region. The biopsy revealed a T-cell-rich primary B cell lymphoma of the skin. Interferon alpha2a was given perilesionally at a dosage of 9 MU three times a week. The treatment was well tolerated, had no severe side-effects and induced a complete remission, both clinically and histologically, during a 12-months course.