Jung W I, Sieverding L, Breuer J, Schmidt O, Widmaier S, Bunse M, van Erckelens F, Apitz J, Dietze G J, Lutz O
Physikalisches Institut, University of Tübingen, Tübingen, 72076, Germany.
J Magn Reson. 1998 Jul;133(1):232-5. doi: 10.1006/jmre.1998.1454.
Proton-decoupled 31P NMR spectroscopy at 1.5 T of the anterior left ventricular myocardium was used to monitor myocardial phosphate metabolism in asymptomatic patients with hypertrophic cardiomyopathy (HCM, n = 14) and aortic stenosis (AS, n = 12). In addition to the well-known phosphorus signals a phosphomonoester (PME) signal was detected at about 6.9 ppm in 7 HCM and 2 AS patients. This signal was not observed in the spectra of normal controls (n = 11). We suggest that in spectra of patients with myocardial hypertrophy the presence of a PME signal reflects alterations in myocardial glucose metabolism.
采用1.5T质子去耦31P核磁共振波谱法，对肥厚型心肌病（HCM，n = 14）和主动脉瓣狭窄（AS，n = 12）的无症状患者左心室前壁心肌的磷酸盐代谢进行监测。除了众所周知的磷信号外，在7例HCM患者和2例AS患者中还检测到约6.9 ppm处的磷酸单酯（PME）信号。正常对照组（n = 11）的光谱中未观察到该信号。我们认为，在心肌肥厚患者的光谱中，PME信号的存在反映了心肌葡萄糖代谢的改变。
