Mimaki Y, Kuroda M, Kameyama A, Yokosuka A, Sashida Y
School of Pharmacy, Tokyo University of Pharmacy and life Science, Japan.
Phytochemistry. 1998 Jun;48(3):485-93. doi: 10.1016/s0031-9422(98)00036-3.
Phytochemical examination of the underground parts of Ruscus aculeatus has been undertaken as part of systematic study of plants of the Liliaceae. Six new spirostanol saponins and five new furostanol saponins were isolated, and their structures were assigned on the basis of spectroscopic analysis, including two-dimensional NMR techniques, and hydrolysis. Ruscogenin diglycoside with three acetyl groups attached to the inner galactosyl moiety and its corresponding 26-glucosyloxyfurostanol saponin showed cytostatic activity on leukemia HL-60 cells.
作为对百合科植物系统研究的一部分，已对刺叶假叶树的地下部分进行了植物化学研究。分离出了六种新的螺旋甾烷醇皂苷和五种新的呋甾烷醇皂苷，并根据光谱分析（包括二维核磁共振技术）和水解确定了它们的结构。在内侧半乳糖基部分连接有三个乙酰基的鲁斯可皂苷元二糖苷及其相应的26-葡萄糖氧基呋甾烷醇皂苷对白血病HL-60细胞具有细胞抑制活性。
