Mimaki Y, Kuroda M, Kameyama A, Yokosuka A, Sashida Y
School of Pharmacy, Tokyo University of Pharmacy and Life Science, Japan.
Chem Pharm Bull (Tokyo). 1998 Feb;46(2):298-303. doi: 10.1248/cpb.46.298.
Phytochemical examination of the underground parts of Ruscus aculeatus has led to the isolation of a total of twelve steroidal saponins, including seven new ones. The structures of the new saponins were determined by spectroscopic analysis and chemical evidence. The furostanol saponin, having a diglycoside moiety modified with a (2S,3S)-2-hydroxy-3-methylpentanoic acid group and an acetic acid group, and its corresponding spirostanol saponin exhibited cytostatic activity on leukemia HL-60 cells.
对刺叶假叶树地下部分进行的植物化学研究已分离出总共12种甾体皂苷，其中包括7种新的甾体皂苷。通过光谱分析和化学证据确定了新皂苷的结构。具有由(2S,3S)-2-羟基-3-甲基戊酸基团和乙酸基团修饰的二糖苷部分的呋甾烷醇皂苷及其相应的螺甾烷醇皂苷对白血病HL-60细胞表现出细胞抑制活性。
