阿弗糖醇，一种来自赤桉的酚类物质，它在体外可抑制前列腺素的生物合成。

Alphitol, a phenolic substance from Alphitonia zizyphoides which inhibits prostaglandin biosynthesis in vitro.

作者信息

Dunstan C, Liu B, Welch C J, Perera P, Bohlin L

机构信息

Department of Pharmacy, Uppsala University, Sweden.

出版信息

Phytochemistry. 1998 Jun;48(3):495-7. doi: 10.1016/s0031-9422(97)00827-3.

DOI:10.1016/s0031-9422(97)00827-3

PMID:9654777

Abstract

The new phenolic compound, 3,5-dihydroxy-4-methoxy phenethyl alcohol, named alphitol, and betulinic acid were from the bark of Alphitonia zizyphoides. The chemical structure of alphitol was determined by mass spectrometry in combination with one and two dimensional NMR, including HMBC. Both compounds inhibited prostaglandin biosynthesis in vitro, alphitol with an IC50 value of 0.66mM, which is of the same magnitude as acetyl salicylic acid.

摘要

新的酚类化合物3,5 - 二羟基 - 4 - 甲氧基苯乙醇（命名为alphitol）和桦木酸来自于菲律宾朴树的树皮。alphitol的化学结构通过质谱结合一维和二维核磁共振（包括HMBC）来确定。两种化合物在体外均抑制前列腺素生物合成，alphitol的IC50值为0.66mM，与乙酰水杨酸的抑制程度相当。