来自黄花马缨丹具有体外抗炎活性的苯乙醇苷类化合物。
Phenylethanoid glycosides from Lantana fucata with in vitro anti-inflammatory activity.
作者信息
Julião Lisieux de Santana, Piccinelli Anna Lisa, Marzocco Stefania, Leitão Suzana Guimarães, Lotti Cinzia, Autore Giuseppina, Rastrelli Luca
机构信息
Programa de Biotecnologia Vegetal, Faculdade de Farmacia, Universidade Federal do Rio de Janeiro, CCS, Bl. A, 2 andar, Ilha do Fundao, 21.941-590, Rio de Janeiro, RJ, Brazil.
出版信息
J Nat Prod. 2009 Aug;72(8):1424-8. doi: 10.1021/np9002383.
A phytochemical analysis of Lantana fucata dried leaves led to the isolation of three new phenylethanoid glycosides, fucatosides A-C, along with parvifloroside A and six known methoxyflavones. Their structures were established by NMR and ESIMS experiments. In vitro assays showed that the alcoholic extract and fucatoside C have significant anti-inflammatory effects, inhibiting NO release in the LPS-induced J774.A1 murine macrophage cell line.
对马缨丹干燥叶进行植物化学分析，从中分离出三种新的苯乙醇苷类化合物，即马缨丹苷A - C，以及小花苷A和六种已知的甲氧基黄酮。通过核磁共振（NMR）和电喷雾离子质谱（ESIMS）实验确定了它们的结构。体外试验表明，乙醇提取物和马缨丹苷C具有显著的抗炎作用，可抑制脂多糖（LPS）诱导的J774.A1小鼠巨噬细胞系中一氧化氮（NO）的释放。
Zotero 插件