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金属中毒中的螯合作用。VI. 对氨基水杨酸（PAS）和环己二胺四乙酸（CDTA）对给予二氧化锰的家兔锰排泄的影响。

Chelation in metal intoxication. VI. Influence of PAS and CDTA on the excretion of manganese in rabbits given MnO2.

作者信息

Tandon S K

出版信息

Toxicology. 1978 Apr;9(4):379-85. doi: 10.1016/0300-483x(78)90021-5.

DOI:10.1016/0300-483x(78)90021-5
PMID:96549
Abstract

The success of p-aminosalicyclic acid (PAS) and 1,2-cyclohexylene dinitrilotetraacetic acid (CDTA) in the mobilization of manganese from some vital organs and their subcellular fractions of manganese-intoxicated rats, led to the two compounds beng further investigated individually and in combination for their efficacy in influencing excretion of manganese in rabbits given MnO2. These chelating agents led to a higher excretion of manganese through faeces than urine. Whereas CDTA was able to enhance the excretion of manganese significantly through both routes, PAS could do so through faeces only. However, the combination did not improve upon the effect of the individual compounds.

摘要

对氨基水杨酸（PAS）和1,2 - 环己二胺四乙酸（CDTA）成功地使锰中毒大鼠的某些重要器官及其亚细胞部分的锰动员出来，这使得对这两种化合物分别以及联合使用进行进一步研究，以考察它们对给予二氧化锰的家兔体内锰排泄的影响效果。这些螯合剂使锰通过粪便的排泄量高于尿液。虽然CDTA能够显著提高锰通过这两种途径的排泄量，但PAS仅能提高锰通过粪便的排泄量。然而，联合使用并未比单独使用这两种化合物的效果更好。

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