十六烷基磷胆碱对线粒体磷脂降解的影响。

The effect of hexadecylphosphocholine on the degradation of mitochondrial phospholipids.

作者信息

Vagina O, Gellerich F N, Ulbrich-Hofmann R

机构信息

Department of Biophysics, Faculty of Biology, Tashkent State University, Uzbekistan.

出版信息

Mol Cell Biochem. 1998 Jun;183(1-2):169-73. doi: 10.1023/a:1006826122602.

DOI:10.1023/a:1006826122602

PMID:9655193

Abstract

Hexadecylphosphocholine (HePC) is known as antitumor agent but the mechanism has not yet been understood. In rat liver mitochondria its effect on phospholipid transformation has been studied by quantitative HPTLC and phosphorus determination. From the results it can be concluded that HePC influences the activities of phospholipase A2, phospholipase C, phospholipase D, and lysophospholipase A. The phospholipid transformation as well as the influence of HePC are affected by exogenous calcium ions. In the presence of calcium HePC has been found to inhibit enzyme activities, whereas in the absence of exogenous calcium ions enzymatic phospholipid transformations are activated or inhibited depending on HePC concentrations.

摘要

十六烷基磷胆碱（HePC）被认为是一种抗肿瘤药物，但其作用机制尚不清楚。在大鼠肝线粒体中，通过定量高效薄层色谱法（HPTLC）和磷测定研究了其对磷脂转化的影响。从结果可以得出结论，HePC影响磷脂酶A2、磷脂酶C、磷脂酶D和溶血磷脂酶A的活性。磷脂转化以及HePC的影响受到外源钙离子的影响。已发现，在有钙离子存在的情况下，HePC会抑制酶活性，而在没有外源钙离子的情况下，酶促磷脂转化根据HePC浓度被激活或抑制。