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Alkylphosphocholines: a new class of membrane-active anticancer agents.

作者信息

Hilgard P, Klenner T, Stekar J, Unger C

机构信息

ASTA Medica AG, Frankfurt am Main.

出版信息

Cancer Chemother Pharmacol. 1993;32(2):90-5. doi: 10.1007/BF00685608.

DOI:10.1007/BF00685608
PMID:8485813
Abstract
摘要

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1
Alkylphosphocholines: a new class of membrane-active anticancer agents.烷基磷胆碱：一类新型的膜活性抗癌药物。
Cancer Chemother Pharmacol. 1993;32(2):90-5. doi: 10.1007/BF00685608.
2
The development of alkylphosphocholines as signal transduction inhibitors: experimental and clinical challenges.烷基磷胆碱作为信号转导抑制剂的研发：实验与临床挑战
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3
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4
In vitro and in vivo antitumoral activity of alkylphosphonates.
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5
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6
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PLoS Negl Trop Dis. 2017 Aug 25;11(8):e0005853. doi: 10.1371/journal.pntd.0005853. eCollection 2017 Aug.
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Perifosine , an oral, anti-cancer agent and inhibitor of the Akt pathway: mechanistic actions, pharmacodynamics, pharmacokinetics, and clinical activity.培非司亭，一种口服抗癌药和 Akt 通路抑制剂：作用机制、药效学、药代动力学和临床活性。
Expert Opin Drug Metab Toxicol. 2012 May;8(5):623-33. doi: 10.1517/17425255.2012.681376.
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Lysolipid containing liposomes for transendothelial drug delivery.用于跨内皮药物递送的含溶血脂质脂质体。
BMC Res Notes. 2012 Apr 10;5:179. doi: 10.1186/1756-0500-5-179.
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Potential involvement of F0F1-ATP(synth)ase and reactive oxygen species in apoptosis induction by the antineoplastic agent erucylphosphohomocholine in glioblastoma cell lines : a mechanism for induction of apoptosis via the 18 kDa mitochondrial translocator protein.反式-二十二碳烯基磷酰胆碱通过诱导 18kDa 线粒体转位蛋白诱导神经胶质瘤细胞凋亡：F0F1-ATP 合酶和活性氧的潜在作用
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蛋白激酶C抑制剂增强顺二氯二氨铂（II）和氮芥的抗增殖作用。
Int J Cancer. 1988 Sep 15;42(3):382-8. doi: 10.1002/ijc.2910420313.
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Characterization of the antitumor activity of hexadecylphosphocholine (D 18506).
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Specific interaction between phosphatidylinositol 4,5-bisphosphate and profilactin.磷脂酰肌醇4,5-二磷酸与肌动蛋白单体结合蛋白之间的特异性相互作用。
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Synergistic enhancement of the antiproliferative activity of cis-diamminedichloroplatinum(II) by the ether lipid analogue BM41440, an inhibitor of protein kinase C.醚脂类似物BM41440（一种蛋白激酶C抑制剂）对顺二氨二氯铂（II）抗增殖活性的协同增强作用。
Lipids. 1989 Apr;24(4):312-7. doi: 10.1007/BF02535169.
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The specific inhibitor of protein kinase C, 1-(5-isoquinolinylsulfonyl)-2-methylpiperazine (H7), induces morphological change and cell differentiation of human neural crest-derived cell lineages.蛋白激酶C的特异性抑制剂1-(5-异喹啉磺酰基)-2-甲基哌嗪（H7）可诱导人神经嵴衍生细胞系发生形态变化和细胞分化。
FEBS Lett. 1990 Aug 20;269(1):4-6. doi: 10.1016/0014-5793(90)81104-v.
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In vitro investigations on the antineoplastic effect of hexadecylphosphocholine.十六烷基磷胆碱抗肿瘤作用的体外研究。
Arzneimittelforschung. 1991 Jun;41(6):652-5.
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Hexadecylphosphocholine-mediated enhancement of T-cell responses to interleukin 2.
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