Kawano A, Seldon H L, Clark G M, Ramsden R T, Raine C H
Department of Otolaryngology, University of Melbourne, Victoria, Australia.
Acta Otolaryngol. 1998 Jun;118(3):313-26. doi: 10.1080/00016489850183386.
The performance of cochlear implant patients may be related to intracochlear, histopathological factors. We have performed detailed post-mortem examinations of five human, implanted cochleas and for each electrode correlated the psychophysical threshold, comfortable level and dynamic range with spiral ganglion cell survival, presence of fibrous tissue and/or new bone, and distance between the centers of the electrode bands and Rosenthal's canal. The psychophysical parameters were strongly interrelated. Threshold and comfort levels correlated with the distance between the electrodes and Rosenthal's canal. Threshold levels also correlated with the presence of intracochlear fibrous tissue and new bone, especially with the former. The dynamic range showed a negative correlation with intracochlear pathology, especially with new bone. Comfort levels and dynamic range were related to spiral ganglion cell survival. The distance between the electrodes and the modiolus increased with increasing levels of fibrous tissue and new bone. Spiral ganglion cell survival was decreased with increasing levels of fibrous tissue and new bone.
人工耳蜗植入患者的表现可能与耳蜗内的组织病理学因素有关。我们对五个人类植入耳蜗进行了详细的尸检，对于每个电极，将心理物理学阈值、舒适响度级和动态范围与螺旋神经节细胞存活情况、纤维组织和/或新骨的存在以及电极带中心与罗斯enthal管之间的距离进行了关联。心理物理学参数之间密切相关。阈值和舒适响度级与电极和罗斯enthal管之间的距离相关。阈值水平也与耳蜗内纤维组织和新骨的存在相关，尤其是与前者相关。动态范围与耳蜗内病理情况呈负相关，尤其是与新骨相关。舒适响度级和动态范围与螺旋神经节细胞存活情况有关。随着纤维组织和新骨水平的增加，电极与蜗轴之间的距离增大。随着纤维组织和新骨水平的增加，螺旋神经节细胞存活率降低。
