Crawford F, Kozono H, White J, Marrack P, Kappler J
Howard Hughes Medical Institute, Division of Basic Immunology, National Jewish Medical and Research Center, Denver, Colorado 80206, USA.
Immunity. 1998 Jun;8(6):675-82. doi: 10.1016/s1074-7613(00)80572-5.
Multimeric soluble MHC class II molecules stably occupied with covalently attached peptides bind with appropriate specificity to T cell hybridomas and T cells from T cell receptor transgenic mice. There is a direct correlation between soluble T cell receptor affinity for monomeric MHC/peptide and level of binding of multimeric MHC/peptide to T cells. While binding of the multimeric MHC/peptide complex is proportional to T cell receptor affinity and expression level, there is little influence of T cell CD4.
稳定结合有共价连接肽段的多聚体可溶性MHC II类分子，能以适当的特异性与T细胞杂交瘤以及来自T细胞受体转基因小鼠的T细胞结合。可溶性T细胞受体对单体MHC/肽段的亲和力与多聚体MHC/肽段与T细胞的结合水平之间存在直接相关性。虽然多聚体MHC/肽段复合物的结合与T细胞受体亲和力和表达水平成正比，但T细胞CD4的影响很小。
