Regensteiner J G, Bauer T A, Reusch J E, Brandenburg S L, Sippel J M, Vogelsong A M, Smith S, Wolfel E E, Eckel R H, Hiatt W R
Section of Vascular Medicine, Department of Medicine, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA.
J Appl Physiol (1985). 1998 Jul;85(1):310-7. doi: 10.1152/jappl.1998.85.1.310.
Persons with type II diabetes mellitus (DM), even without cardiovascular complications have a decreased maximal oxygen consumption (VO2 max) and submaximal oxygen consumption (VO2) during graded exercise compared with healthy controls. We evaluated the hypothesis that change in the rate of VO2 in response to the onset of constant-load exercise (measured by VO2-uptake kinetics) was slowed in persons with type II DM. Ten premenopausal women with uncomplicated type II DM, 10 overweight, nondiabetic women, and 10 lean, nondiabetic women had a VO2 max test. On two separate occasions, subjects performed 7-min bouts of constant-load bicycle exercise at workloads below and above the lactate threshold to enable measurements of VO2 kinetics and heart rate kinetics (measuring rate of heart rate rise). VO2 max was reduced in subjects with type II DM compared with both lean and overweight controls (P < 0.05). Subjects with type II DM had slower VO2 and heart rate kinetics than did controls at constant workloads below the lactate threshold. The data suggest a notable abnormality in the cardiopulmonary response at the onset of exercise in people with type II DM. The findings may reflect impaired cardiac responses to exercise, although an additional defect in skeletal muscle oxygen diffusion or mitochondrial oxygen utilization is also possible.
与健康对照组相比，II型糖尿病（DM）患者即使没有心血管并发症，在分级运动期间的最大摄氧量（VO2 max）和次最大摄氧量（VO2）也会降低。我们评估了这样一个假设：II型糖尿病患者对恒定负荷运动开始时VO2速率的变化（通过VO2摄取动力学测量）会减慢。10名无并发症的绝经前II型糖尿病女性、10名超重的非糖尿病女性和10名消瘦的非糖尿病女性进行了VO2 max测试。在两个不同的场合，受试者在低于和高于乳酸阈值的工作负荷下进行了7分钟的恒定负荷自行车运动，以测量VO2动力学和心率动力学（测量心率上升速率）。与消瘦和超重对照组相比，II型糖尿病患者的VO2 max降低（P < 0.05）。在低于乳酸阈值的恒定工作负荷下，II型糖尿病患者的VO2和心率动力学比对照组慢。数据表明，II型糖尿病患者在运动开始时心肺反应存在明显异常。这些发现可能反映了心脏对运动的反应受损，尽管骨骼肌氧扩散或线粒体氧利用方面的额外缺陷也有可能。
