Samlal R A, Ten Kate F J, Hart A A, Lammes F B
Department of Obstetrics and Gynecology, University of Amsterdam, The Netherlands.
Int J Gynecol Pathol. 1998 Jul;17(3):201-4. doi: 10.1097/00004347-199807000-00002.
Twenty-nine patients with stage IB/IIA squamous cell carcinoma of the uterine cervix who had positive pelvic nodes were matched with 29 cases of node-negative squamous cell carcinoma by depth of invasion and lymphovascular space invasion. By multivariate analysis, these criteria independently predicted pelvic node metastases. Intracellular mucin, demonstrated by alcian-blue staining at pH 2.5, was noted in 21 of the 58 patients (36%). The frequency of mucin-positive tumors was not significantly different between the patients and their controls (38 versus 34%, p = 0.78), nor was the degree of positivity. These results suggest that, although a substantial proportion of squamous cell carcinomas exhibit mucin secretion, patients with these tumors are not at increased risk for pelvic node metastases. We therefore do not recommend routine mucin staining in cervical squamous cell carcinomas.
29例子宫颈IB/IIA期鳞状细胞癌且盆腔淋巴结阳性的患者，根据浸润深度和脉管间隙浸润情况，与29例淋巴结阴性的鳞状细胞癌患者进行匹配。多因素分析显示，这些标准可独立预测盆腔淋巴结转移。58例患者中有21例（36%）经pH 2.5的阿尔辛蓝染色显示存在细胞内黏蛋白。黏蛋白阳性肿瘤的发生率在患者及其对照之间无显著差异（38%对34%，p = 0.78），阳性程度亦无差异。这些结果表明，虽然相当一部分鳞状细胞癌表现出黏蛋白分泌，但这些肿瘤患者发生盆腔淋巴结转移的风险并未增加。因此，我们不建议对宫颈鳞状细胞癌进行常规黏蛋白染色。
