近交系大鼠中的反应素合成。II. 反应素抗体合成的遗传控制。
Reagin synthesis in inbred rats. II. Genetic control of reaginic antibody synthesis.
作者信息
Murphey S M, White C, Waters T, Fireman P
出版信息
J Allergy Clin Immunol. 1976 Sep;58(3):381-6. doi: 10.1016/0091-6749(76)90118-4.
Specific reaginic (IgE) and hemagglutinating (IgG) antibodies were quantified after immunization with ovalbumin aluminum hydroxide gel in BN and ACI inbred rats, as well as their F1, F1 X BN backcross, F2, and F3, and F3 progeny. The dissimilarity of these immune responses indicated that reaginic (IgE) antibody synthesis was influenced by polygenic factors, but not sex, and was controlled by loci different from that governing hemagglutinating (IgG) antibody synthesis. In addition, tissue typing of the BN, ACI, F1, and F3 hybrids suggested that reaginic antibody synthesis was not linked to the major rat histocompatibility locus.
在用卵清蛋白氢氧化铝凝胶免疫BN和ACI近交系大鼠及其F1、F1与BN的回交后代、F2、F3和F3子代后，对特异性反应素（IgE）和血凝（IgG）抗体进行了定量分析。这些免疫反应的差异表明，反应素（IgE）抗体的合成受多基因因素影响，但不受性别影响，且由与控制血凝（IgG）抗体合成的基因座不同的基因座控制。此外，对BN、ACI、F1和F3杂种的组织分型表明，反应素抗体的合成与大鼠主要组织相容性基因座无关。
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