Monden Y
Second Department of Surgery, University of Tokushima School of Medicine, Japan.
Nihon Geka Gakkai Zasshi. 1998 May;99(5):308-11.
Surgery is the first-line therapy for thymoma. Postoperative radiotherapy should be given for all invasive thymomas, followed by chemotherapy in some cases. Even if the resection is not complete, surgery is effective therapy because most thymomas are local and slow growing. Multidrug chemotherapy including cisplatin is effective against thymoma. Thymic cancer is histologically varied. Surgery is only one effective therapy for thymic cancer. Although no definitive chemotherapy regimen for thymic cancer has yet been established, we feel that the cisplatin, doxorubicin, cyclophosphamide, vincristine 4-drug combination regimen is effective in thymic cancer patients. Seminoma out of mediastinal germ cell tumor (GCT) is expected to have a good prognosis after surgery and radio-/chemotherapy. Although the prognosis for those with nonseminomatous GCT has recently improved due to chemotherapy and surgery, it is still poor.
手术是胸腺瘤的一线治疗方法。所有侵袭性胸腺瘤术后均应进行放疗，部分病例随后进行化疗。即使切除不完全，手术仍是有效的治疗方法，因为大多数胸腺瘤是局限性的且生长缓慢。包括顺铂在内的多药化疗对胸腺瘤有效。胸腺癌在组织学上具有多样性。手术是胸腺癌唯一有效的治疗方法。虽然尚未确立针对胸腺癌的明确化疗方案，但我们认为顺铂、阿霉素、环磷酰胺、长春新碱四联化疗方案对胸腺癌患者有效。纵隔生殖细胞肿瘤（GCT）中的精原细胞瘤在手术及放化疗后预后良好。尽管非精原细胞瘤性GCT患者的预后因化疗和手术最近有所改善，但仍然较差。
