长期使用外用氯化氨基汞所致的周围性多发性神经病。
Peripheral polyneuropathy due to chronic use of topical ammoniated mercury.
作者信息
Deleu D, Hanssens Y, al-Salmy H S, Hastie I
机构信息
College of Medicine, Sultan Qaboos University, Al-Khod, Muscat, Sultanate of Oman.
出版信息
J Toxicol Clin Toxicol. 1998;36(3):233-7. doi: 10.3109/15563659809028945.
BACKGROUND
Despite their potentially disastrous side effects, topical mercury salts can still be found as ingredients in some over-the-counter preparations or local remedies.
CASE REPORT
Peripheral polyneuropathy as a result of chronic ammoniated mercury poisoning was studied and followed over 2 years. A 36-year-old man developed peripheral polyneuropathy following chronic perianal use of an ammoniated mercury ointment. Highly elevated blood and urine mercury levels were found. Sural nerve biopsy showed mixed axonal degeneration-demyelination. There was progressive improvement of his symptoms over 2 years but neurophysiological examination revealed incomplete recovery.
CONCLUSION
The availability of safer drugs should result in a complete ban of these dangerous compounds.
背景
尽管局部使用汞盐可能会产生灾难性的副作用，但在一些非处方制剂或民间疗法中仍可发现其作为成分存在。
病例报告
对慢性氨化汞中毒导致的周围性多发性神经病进行了为期2年的研究及跟踪。一名36岁男性在肛周长期使用氨化汞软膏后出现周围性多发性神经病。发现其血液和尿液中的汞水平大幅升高。腓肠神经活检显示混合性轴索性变性 - 脱髓鞘改变。其症状在2年中逐渐改善，但神经生理学检查显示恢复不完全。
结论
更安全药物的可得性应导致全面禁止这些危险化合物。
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