毛喉素未能提高豚鼠实验性内淋巴积水的内耳蜗电位。

Failure of forskolin to elevate the endocochlear potential in experimental endolymphatic hydrops of the guinea pig.

作者信息

Kitano I, Mori N, Nario K, Umemoto M, Sakagami M, Fukazawa K, Matsunaga T

机构信息

Department of Otolaryngology, Nara Medical University, Kashihara City, Japan.

出版信息

Acta Otolaryngol Suppl. 1998;533:9-11. doi: 10.1080/00016489850183656.

DOI:10.1080/00016489850183656

PMID:9657302

Abstract

The effect of forskolin (FSK) on the endocochlear potential (EP) in scala media (SM) was examined in experimental endolymphatic hydrops of the guinea pig. Two weeks after obliteration of the endolymphatic sac the EP of hydroptic ears and that of the contralateral control ears were measured by means of microelectrodes. The perfusion of scala vestibuli (SV) with FSK (200 microM) produced EP elevation in the contralateral control ears but failed to do so in the experimental hydroptic ears. Histological examination of experimental endolymphatic hydrops showed mild hydrops with intact appearance of outer and inner hair cells, and the stria vascularis. The mechanism underlying the failure of FSK to elevate the EP in experimental endolymphatic hydrops is discussed.

摘要

在豚鼠实验性内淋巴积水模型中，研究了福斯高林（FSK）对蜗管内淋巴电位（EP）的影响。在内淋巴囊闭塞两周后，用微电极测量积水耳和对侧对照耳的EP。用200微摩尔的FSK灌注前庭阶（SV）可使对侧对照耳的EP升高，但在实验性积水耳中则无此作用。实验性内淋巴积水的组织学检查显示有轻度积水，外毛细胞、内毛细胞及血管纹外观完整。本文讨论了FSK不能使实验性内淋巴积水耳的EP升高的潜在机制。