Mori N, Uozumi N, Furuta H, Hoshikawa H
Department of Otolaryngology, Kagawa Medical University, Japan.
Acta Otolaryngol Suppl. 1998;533:12-5.
Acetazolamide (ACTZ), a carbonic anhydrase inhibitor, has been reported to decrease the endolymphatic sac (ES) DC potential (ESP) in the guinea pig. To assess the involvement of cation transport in the ESP change by ACTZ we examined the effect of ACTZ upon the K+ and Na+ activities of the ES endolymph in the guinea pig using ion-sensitive microelectrode. ACTZ (10 mg/kg), a dose that produces the ESP maximum reduction, produced a significant increase in Na+ activity of the ES endolymph with no change in K+ activity. The results suggest that Na+ transport may be directly or indirectly involved in ESP reduction by ACTZ, and that a Na(+)-H+ exchanger may be involved in Na+ influx pathway from endolymph to the ES epithelial cells.
乙酰唑胺（ACTZ）是一种碳酸酐酶抑制剂，据报道它可降低豚鼠内淋巴囊（ES）的直流电位（ESP）。为了评估阳离子转运在ACTZ引起的ESP变化中的作用，我们使用离子敏感微电极研究了ACTZ对豚鼠ES内淋巴中K⁺和Na⁺活性的影响。ACTZ（10mg/kg），即产生ESP最大降幅的剂量，使ES内淋巴的Na⁺活性显著增加，而K⁺活性无变化。结果表明，Na⁺转运可能直接或间接参与了ACTZ引起的ESP降低，并且Na⁺-H⁺交换体可能参与了Na⁺从内淋巴流入ES上皮细胞的途径。
