人类白细胞抗原与恶性原发性高血压

Human leukocyte antigens and malignant essential hypertension.

作者信息

Gerbase-DeLima M, Paiva R L, Bortolotto L A, Bernardes-Silva H, De Lima J J

机构信息

Escola Paulista de Medicina, Universidade Federal de São Paulo, Brazil.

出版信息

Am J Hypertens. 1998 Jun;11(6 Pt 1):729-31. doi: 10.1016/s0895-7061(98)00050-8.

DOI:10.1016/s0895-7061(98)00050-8

PMID:9657633

Abstract

The purpose of this study was to investigate an association between human leukocyte antigens (HLA) and the susceptibility to malignant hypertension. The presence of HLA-A, -B, -DR, and -DQ was determined in 33 white and in 23 mulatto Brazilian patients with malignant essential hypertension. No statistically significant differences were detected between patients and control subjects. It is nevertheless important to note that we have observed an increased frequency of DR3 in the mulatto patients (34.8% v 21.4%). We consider that this finding supports the existence of an HLA-DR3 association with hypertension in the black population, as has been claimed by other authors.

摘要

本研究的目的是调查人类白细胞抗原（HLA）与恶性高血压易感性之间的关联。在33名患有恶性原发性高血压的白种人和23名患有恶性原发性高血压的巴西混血患者中确定了HLA - A、- B、- DR和 - DQ的存在。患者与对照受试者之间未检测到统计学上的显著差异。然而，值得注意的是，我们观察到混血患者中DR3的频率增加（34.8%对21.4%）。我们认为这一发现支持了其他作者所主张的HLA - DR3与黑人人群高血压之间存在关联的观点。