Khaitov R M, Polianskaia I S, Alekseev L P
Ter Arkh. 1990;62(8):70-4.
Tissue typing applied to the Russian population was used to study distribution of HLA antigens, classes I and II, in patients with essential hypertension (EH), coronary heart disease (CHD), hypertrophic cardiomyopathy (HCMP), dilated cardiomyopathy (DCMP) and virus myocarditis (VM). As control use was made of the data on HLA antigen distribution in 267 healthy persons (donors) of the Russian nationality. The genetic markers of the predisposition to the indicated diseases were revealed: in EH, DR 1 (RR-3.56), DR 4 (RR-2.17); in CHD, B 12 (RR-2.91), DR 1 (RR-3.41), DR 4 (RR-3.14); in HCMP, DR 1 (RR-2.25), DR 4 (RR-3.29); in DCMP, DR 4 (RR-3.90); in VM, DR 3 (RR-5.26), DR 4 (RR-3.51). DR 4 turned out to be the common marker of the predisposition to cardiac diseases. Besides, DR 1 was discovered to be the marker of the predisposition to EH and DR 3 to VM. The data obtained may be of importance for the clinical practice in forming risk groups.
对俄罗斯人群进行组织分型，以研究HLA I类和II类抗原在原发性高血压（EH）、冠心病（CHD）、肥厚型心肌病（HCMP）、扩张型心肌病（DCMP）和病毒性心肌炎（VM）患者中的分布情况。以267名俄罗斯籍健康人（供体）的HLA抗原分布数据作为对照。揭示了上述疾病易感性的遗传标记：在原发性高血压中，DR 1（相对危险度-3.56），DR 4（相对危险度-2.17）；在冠心病中，B 12（相对危险度-2.91），DR 1（相对危险度-3.41），DR 4（相对危险度-3.14）；在肥厚型心肌病中，DR 1（相对危险度-2.25），DR 4（相对危险度-3.29）；在扩张型心肌病中，DR 4（相对危险度-3.90）；在病毒性心肌炎中，DR 3（相对危险度-5.26），DR 4（相对危险度-3.51）。结果发现DR 4是心脏病易感性的共同标记。此外，还发现DR 1是原发性高血压易感性的标记，DR 3是病毒性心肌炎易感性的标记。所获得的数据对于临床实践中形成风险组可能具有重要意义。
