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The central, surface-exposed region of the flagellar hook protein FlgE of Campylobacter jejuni shows hypervariability among strains.空肠弯曲菌鞭毛钩蛋白FlgE的中央表面暴露区域在菌株间表现出高度变异性。
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The complete genome sequence of Escherichia coli K-12.大肠杆菌K-12的全基因组序列。
Science. 1997 Sep 5;277(5331):1453-62. doi: 10.1126/science.277.5331.1453.
2
Evidence for recombination in the flagellin locus of Campylobacter jejuni: implications for the flagellin gene typing scheme.空肠弯曲菌鞭毛蛋白基因座重组的证据：对鞭毛蛋白基因分型方案的影响。
J Clin Microbiol. 1997 Sep;35(9):2386-92. doi: 10.1128/jcm.35.9.2386-2392.1997.
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The flgE gene of Campylobacter coli is under the control of the alternative sigma factor sigma54.空肠弯曲菌的flgE基因受替代σ因子σ54的调控。
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Roles for motility in bacterial-host interactions.运动性在细菌与宿主相互作用中的作用。
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Pathogenesis of enteric infection by Campylobacter.弯曲杆菌肠道感染的发病机制
Microbiology (Reading). 1997 Jan;143 ( Pt 1):5-21. doi: 10.1099/00221287-143-1-5.
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Characterization of a post-translational modification of Campylobacter flagellin: identification of a sero-specific glycosyl moiety.弯曲杆菌鞭毛蛋白翻译后修饰的表征：血清特异性糖基部分的鉴定。
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Identification and characterization of genes required for post-translational modification of Campylobacter coli VC167 flagellin.空肠弯曲菌VC167鞭毛蛋白翻译后修饰所需基因的鉴定与表征
Mol Microbiol. 1996 Jan;19(2):369-78. doi: 10.1046/j.1365-2958.1996.369895.x.
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Gene inactivation in the oral spirochete Treponema denticola: construction of an flgE mutant.口腔螺旋体齿垢密螺旋体中的基因失活：flgE突变体的构建。
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Structural analysis of the L-methionine gamma-lyase gene from Pseudomonas putida.恶臭假单胞菌L-甲硫氨酸γ-裂合酶基因的结构分析
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The hook protein of Borrelia burgdorferi, encoded by the flgE gene, is serologically recognized in Lyme disease.由flgE基因编码的伯氏疏螺旋体钩蛋白在莱姆病中可被血清学识别。
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空肠弯曲菌鞭毛钩蛋白FlgE的中央表面暴露区域在菌株间表现出高度变异性。

The central, surface-exposed region of the flagellar hook protein FlgE of Campylobacter jejuni shows hypervariability among strains.

作者信息

Lüneberg E, Glenn-Calvo E, Hartmann M, Bär W, Frosch M

机构信息

Institut für Hygiene und Mikrobiologie, Universität Würzburg, Würzburg, Germany.

出版信息

J Bacteriol. 1998 Jul;180(14):3711-4. doi: 10.1128/JB.180.14.3711-3714.1998.

DOI:10.1128/JB.180.14.3711-3714.1998
PMID:9658019
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC107344/
Abstract

In a previous study, we observed that monoclonal antibodies raised against the hook protein FlgE of Campylobacter jejuni LIO 36, isolate 5226, bound exclusively to this strain. The aim of this study was to elucidate the molecular basis for these binding specificities. The hook protein-encoding gene flgE of C. jejuni was cloned in Escherichia coli and sequenced. The flgE genes of four additional C. jejuni strains were amplified by PCR and also sequenced. Comparison of the deduced amino acid sequences revealed a high degree of variability in the central parts of the FlgE proteins among the strains, including variable and hypervariable domains. These findings may indicate a selective pressure of C. jejuni hosts, forcing the bacteria to generate variations in surface-exposed antigenic determinants.

摘要

在之前的一项研究中，我们观察到针对空肠弯曲菌LIO 36（菌株5226）的钩蛋白FlgE产生的单克隆抗体仅与该菌株结合。本研究的目的是阐明这些结合特异性的分子基础。空肠弯曲菌的钩蛋白编码基因flgE在大肠杆菌中克隆并测序。另外四个空肠弯曲菌菌株的flgE基因通过PCR扩增并测序。推导的氨基酸序列比较显示，菌株间FlgE蛋白中部存在高度变异性，包括可变区和高变区。这些发现可能表明空肠弯曲菌宿主存在选择性压力，迫使细菌在表面暴露的抗原决定簇中产生变异。