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Role of the Fas/Fas ligand apoptotic pathway in human immunodeficiency virus type 1 disease.Fas/Fas配体凋亡途径在1型人类免疫缺陷病毒疾病中的作用
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2
Role of Fas ligand and receptor in the mechanism of T-cell depletion in acquired immunodeficiency syndrome: effect on CD4+ lymphocyte depletion and human immunodeficiency virus replication.Fas配体和受体在获得性免疫缺陷综合征中T细胞耗竭机制中的作用：对CD4+淋巴细胞耗竭及人类免疫缺陷病毒复制的影响
Blood. 1997 Feb 15;89(4):1357-63.
3
Role of FAS in HIV infection.FAS在HIV感染中的作用。
Curr HIV Res. 2003 Oct;1(4):405-17. doi: 10.2174/1570162033485131.
4
Effect of L-carnitine on human immunodeficiency virus-1 infection-associated apoptosis: a pilot study.左旋肉碱对人类免疫缺陷病毒1型感染相关细胞凋亡的影响：一项初步研究。
Blood. 1998 May 15;91(10):3817-24.
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Fas/FasL interaction is not involved in apoptosis of activated CD4+ T cells upon HIV-1 infection in vitro.在体外HIV-1感染时，Fas/FasL相互作用不参与活化的CD4+ T细胞的凋亡。
J Acquir Immune Defic Syndr Hum Retrovirol. 1998 Aug 1;18(4):307-15. doi: 10.1097/00042560-199808010-00001.
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Fas ligand-mediated depletion of CD4 and CD8 lymphocytes by monomeric HIV-1-gp120.单体HIV-1-gp120通过Fas配体介导使CD4和CD8淋巴细胞耗竭。
Arch Virol. 1997;142(9):1771-85. doi: 10.1007/s007050050196.
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HIV-1 upregulates Fas ligand expression in CD4+ T cells in vitro and in vivo: association with Fas-mediated apoptosis and modulation by aurintricarboxylic acid.HIV-1在体外和体内均可上调CD4⁺T细胞中Fas配体的表达：与Fas介导的细胞凋亡相关以及金精三羧酸的调节作用
Immunology. 1996 Apr;87(4):581-5. doi: 10.1046/j.1365-2567.1996.510589.x.
8
HIV-induced apoptosis of activated primary CD4+ T lymphocytes is not mediated by Fas-Fas ligand.人类免疫缺陷病毒（HIV）诱导的活化原代CD4 + T淋巴细胞凋亡并非由Fas-Fas配体介导。
AIDS. 1997 Nov 15;11(14):1671-80. doi: 10.1097/00002030-199714000-00003.
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TNF receptor 2-deficient CD8 T cells are resistant to Fas/Fas ligand-induced cell death.肿瘤坏死因子受体2缺陷的CD8 T细胞对Fas/Fas配体诱导的细胞死亡具有抗性。
J Immunol. 2000 Nov 1;165(9):4814-21. doi: 10.4049/jimmunol.165.9.4814.
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Upregulation of Fas ligand expression by human immunodeficiency virus in human macrophages mediates apoptosis of uninfected T lymphocytes.人类免疫缺陷病毒在人巨噬细胞中上调Fas配体表达，介导未感染T淋巴细胞的凋亡。
J Virol. 1996 Jan;70(1):199-206. doi: 10.1128/JVI.70.1.199-206.1996.

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1
CD4+ T cells in HIV infection show increased levels of expression of a receptor for vasoactive intestinal peptide, VPAC2.感染HIV的CD4 + T细胞中血管活性肠肽受体VPAC2的表达水平升高。
Immunol Res. 2014 Oct;60(1):11-5. doi: 10.1007/s12026-014-8487-2.
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Foxo3a: an integrator of immune dysfunction during HIV infection.Foxo3a：HIV 感染期间免疫功能障碍的整合因子。
Cytokine Growth Factor Rev. 2012 Aug-Oct;23(4-5):215-21. doi: 10.1016/j.cytogfr.2012.05.008. Epub 2012 Jun 27.
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HIV gp41 engages gC1qR on CD4+ T cells to induce the expression of an NK ligand through the PIP3/H2O2 pathway.HIV gp41 与 CD4+ T 细胞上的 gC1qR 结合，通过 PIP3/H2O2 途径诱导 NK 配体的表达。
PLoS Pathog. 2010 Jul 1;6(7):e1000975. doi: 10.1371/journal.ppat.1000975.
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Attenuated disease in SIV-infected macaques treated with a monoclonal antibody against FasL.用抗FasL单克隆抗体治疗的感染SIV的猕猴中的减毒疾病。
Clin Dev Immunol. 2007;2007:93462. doi: 10.1155/2007/93462.
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Inhibition of NF-kappa B activity and cFLIP expression contribute to viral-induced apoptosis.抑制核因子-κB活性和cFLIP表达有助于病毒诱导的细胞凋亡。
Apoptosis. 2005 May;10(3):513-24. doi: 10.1007/s10495-005-1881-4.
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The Nef-mediated AIDS-like disease of CD4C/human immunodeficiency virus transgenic mice is associated with increased Fas/FasL expression on T cells and T-cell death but is not prevented in Fas-, FasL-, tumor necrosis factor receptor 1-, or interleukin-1beta-converting enzyme-deficient or Bcl2-expressing transgenic mice.Nef介导的CD4C/人类免疫缺陷病毒转基因小鼠的类艾滋病疾病与T细胞上Fas/FasL表达增加及T细胞死亡相关，但在Fas、FasL、肿瘤坏死因子受体1或白细胞介素-1β转换酶缺陷或表达Bcl2的转基因小鼠中并未得到预防。
J Virol. 2005 May;79(10):6377-91. doi: 10.1128/JVI.79.10.6377-6391.2005.
7
Apoptosis of uninfected cells induced by HIV envelope glycoproteins.由HIV包膜糖蛋白诱导的未感染细胞的凋亡。
Retrovirology. 2004 Jun 23;1:12. doi: 10.1186/1742-4690-1-12.
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Increased Fas-mediated apoptosis in polymorphonuclear cells from HIV-infected patients.来自HIV感染患者的多形核细胞中Fas介导的细胞凋亡增加。
Clin Exp Immunol. 2004 Jul;137(1):166-72. doi: 10.1111/j.1365-2249.2004.02503.x.
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Vitamin E inhibits CD95 ligand expression and protects T cells from activation-induced cell death.维生素E抑制CD95配体的表达，并保护T细胞免受激活诱导的细胞死亡。
J Clin Invest. 2002 Sep;110(5):681-90. doi: 10.1172/JCI15073.
10
Exogenous interleukin-2 administration corrects the cell cycle perturbation of lymphocytes from human immunodeficiency virus-infected individuals.外源性白细胞介素-2的施用可纠正人类免疫缺陷病毒感染个体淋巴细胞的细胞周期紊乱。
J Virol. 2001 Nov;75(22):10843-55. doi: 10.1128/JVI.75.22.10843-10855.2001.

本文引用的文献

1
Ligation of cell surface CD4 inhibits activation-induced death of human T lymphocytes at the level of Fas ligand expression.细胞表面CD4的结扎在Fas配体表达水平抑制人T淋巴细胞的激活诱导死亡。
J Immunol. 1997 Dec 1;159(11):5742-9.
2
Downregulation of Fas ligand by shedding.通过脱落使Fas配体下调。
Nat Med. 1998 Jan;4(1):31-6. doi: 10.1038/nm0198-031.
3
Membrane Fas ligand kills human peripheral blood T lymphocytes, and soluble Fas ligand blocks the killing.膜型Fas配体可杀伤人类外周血T淋巴细胞，而可溶性Fas配体可阻断这种杀伤作用。
J Exp Med. 1997 Dec 15;186(12):2045-50. doi: 10.1084/jem.186.12.2045.
4
A major human immunodeficiency virus type 1-initiated killing pathway distinct from apoptosis.一种不同于凋亡的主要由1型人类免疫缺陷病毒引发的杀伤途径。
J Virol. 1997 Dec;71(12):9753-63. doi: 10.1128/JVI.71.12.9753-9763.1997.
5
HIV-1 Vpr suppresses immune activation and apoptosis through regulation of nuclear factor kappa B.人类免疫缺陷病毒1型病毒蛋白R通过调节核因子κB抑制免疫激活和细胞凋亡。
Nat Med. 1997 Oct;3(10):1117-23. doi: 10.1038/nm1097-1117.
6
Interleukin-1 beta converting enzyme-like protease involvement in Fas-induced and activation-induced peripheral blood T cell apoptosis in HIV infection. TNF-related apoptosis-inducing ligand can mediate activation-induced T cell death in HIV infection.白细胞介素-1β转化酶样蛋白酶参与HIV感染中Fas诱导及激活诱导的外周血T细胞凋亡。肿瘤坏死因子相关凋亡诱导配体可介导HIV感染中激活诱导的T细胞死亡。
J Exp Med. 1997 Oct 20;186(8):1365-72. doi: 10.1084/jem.186.8.1365.
7
Elevated serum level of Fas ligand correlates with the asymptomatic stage of human immunodeficiency virus infection.血清Fas配体水平升高与人类免疫缺陷病毒感染的无症状期相关。
Blood. 1997 Jul 15;90(2):896-8.
8
Evasion of cytotoxic T lymphocyte (CTL) responses by nef-dependent induction of Fas ligand (CD95L) expression on simian immunodeficiency virus-infected cells.通过在感染猿猴免疫缺陷病毒的细胞上依赖nef诱导Fas配体（CD95L）表达来逃避细胞毒性T淋巴细胞（CTL）反应。
J Exp Med. 1997 Jul 7;186(1):7-16. doi: 10.1084/jem.186.1.7.
9
Human immunodeficiency virus type 1 Vpr induces apoptosis following cell cycle arrest.1型人类免疫缺陷病毒Vpr在细胞周期停滞后诱导细胞凋亡。
J Virol. 1997 Jul;71(7):5579-92. doi: 10.1128/JVI.71.7.5579-5592.1997.
10
Apoptosis in HIV-infected individuals is an early marker occurring independently of high viremia.HIV感染者体内的细胞凋亡是一种独立于高病毒血症发生的早期标志物。
AIDS Res Hum Retroviruses. 1997 Jun 10;13(9):771-9. doi: 10.1089/aid.1997.13.771.

Role of the Fas/Fas ligand apoptotic pathway in human immunodeficiency virus type 1 disease.

作者信息

Kaplan D, Sieg S

机构信息

The Institute of Pathology, Case Western Reserve University, Cleveland, Ohio 44106-4943, USA.

出版信息

J Virol. 1998 Aug;72(8):6279-82. doi: 10.1128/JVI.72.8.6279-6282.1998.

DOI:10.1128/JVI.72.8.6279-6282.1998
PMID:9658065
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC109763/
Abstract
摘要