一种新型痘苗病毒中间转录因子。
A new vaccinia virus intermediate transcription factor.
作者信息
Sanz P, Moss B
机构信息
Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892-0445, USA.
出版信息
J Virol. 1998 Aug;72(8):6880-3. doi: 10.1128/JVI.72.8.6880-6883.1998.
Abstract
Transcription of the vaccinia virus genome is mediated by a virus-encoded multisubunit DNA-dependent RNA polymerase in conjunction with early-, intermediate-, and late-stage-specific factors. Previous studies indicated that two virus-encoded proteins (capping enzyme and VITF-1) and one unidentified cellular protein (VITF-2) are required for specific transcription of an intermediate promoter template in vitro. We have now extensively purified an additional virus-induced intermediate transcription factor with a native mass of approximately 100 kDa.
摘要
痘苗病毒基因组的转录由一种病毒编码的多亚基DNA依赖性RNA聚合酶与早期、中期和晚期特异性因子共同介导。先前的研究表明，在体外，中间启动子模板的特异性转录需要两种病毒编码蛋白（加帽酶和VITF-1）和一种未鉴定的细胞蛋白（VITF-2）。我们现在已经广泛纯化了另一种病毒诱导的中间转录因子，其天然质量约为100 kDa。
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本文引用的文献
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An ATPase component of the transcription elongation complex is required for factor-dependent transcription termination by vaccinia RNA polymerase.痘苗病毒RNA聚合酶依赖因子的转录终止需要转录延伸复合物的一种ATP酶成分。
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