Liso V, Specchia G, Pannunzio A, Mestice A, Palumbo G, Biondi A
Divisione di Ematologia, Università di Bari, Italy.
Haematologica. 1998 May;83(5):471-3.
Secondary acute lymphoblastic leukemia (sALL) following acute myeloid leukemia (AML) is a rare event; only eight cases have been reported. We report a patient with acute promyelocytic leukemia (APL), in hematological and molecular remission who developed T-ALL three years after the diagnosis of APL. The morphological, cytochemical, phenotypical and molecular features of this T-ALL were different from those of the previous APL. The absence of t(15;17), negative PML/RAR alpha at reverse transcription polymerase chain reaction (RT-PCR) analysis and presence of TcR delta support the hypothesis that the T-ALL in this sALL case originated from a different clone from that of the APL cells.
急性髓系白血病（AML）后继发的急性淋巴细胞白血病（sALL）是一种罕见事件；仅报告过8例。我们报告1例急性早幼粒细胞白血病（APL）患者，该患者处于血液学和分子学缓解状态，在APL诊断3年后发生了T细胞急性淋巴细胞白血病（T-ALL）。该T-ALL的形态学、细胞化学、表型和分子特征与先前的APL不同。缺乏t(15;17)、逆转录聚合酶链反应（RT-PCR）分析中PML/RARα阴性以及存在TcRδ支持了这一假说，即该sALL病例中的T-ALL起源于与APL细胞不同的克隆。
