Bee P C, Gan G G, Sangkar J V, Teh A, Goh K Y
Department of Medicine, Faculty of Medicine, University Malaya, Kuala Lumpur, Malaysia.
Int J Hematol. 2004 May;79(4):358-60. doi: 10.1532/ijh97.a20304.
We diagnosed T-cell acute lymphoblastic leukemia (T-ALL) with multiple cytogenetic abnormalities in a 17-year-old girl a year after she had received a diagnosis of acute promyelocytic leukemia (APML). After the diagnosis of APML in June 2001, the patient was treated with idarubicin and all-trans-retinoic acid. In September 1999, her younger sister also received a diagnosis of APML and to date has remained well. T-ALL after remission of APML is very rare, and only 1 such case has been reported. Possible causes include therapy-related reasons, genetic susceptibility to leukemia, and environmental exposure.
