Jáuregui-Renaud K, Domínguez-Rubio B, Ibarra-Olmos A, González-Bárcena D
Departamento de Audiología y Otoneurologia, Centro Médico Nacional La Raza, Instituto Mexicano del Seguro Social, México DF.
Rev Invest Clin. 1998 Mar-Apr;50(2):137-8.
To assess the auditory and vestibular function in patients with diabetes.
We studied and followed for three years, 10 patients (6 females) of 20.6 years of age (SD 5.5 years), with insulindependent diabetes mellitus of 9.5 years (SD 3.7 years). The patients were selected for having peripheral neuropathy without prolipherative retinopathy and otologic disease or individual factors which could cause neurootologic symptoms. Their glomerular filtration rate and renal plasma flow were 150 mL/min (SD 50) and 543 mL/min (SD 113).
Initially all patients had normal audiologic responses, including auditory brainstem responses, but had abnormally and simetrically diminished horizontal vestibulo-ocular responses. A year later one patient had vertigo and asymmetric vestibulo-ocular responses. In the third year, another patient showed similar abnormalities and a third one showed sensorineural hearing loss.
Our results suggest that patients with insulindependent diabetes mellitus may suffer neuro-otological deterioration.
评估糖尿病患者的听觉和前庭功能。
我们对10名患者（6名女性）进行了为期三年的研究与随访，这些患者平均年龄20.6岁（标准差5.5岁），患胰岛素依赖型糖尿病9.5年（标准差3.7年）。入选患者患有周围神经病变，但无增殖性视网膜病变及耳科疾病或可导致神经耳科症状的个体因素。他们的肾小球滤过率和肾血浆流量分别为150毫升/分钟（标准差50）和543毫升/分钟（标准差113）。
最初，所有患者的听力学反应均正常，包括听觉脑干反应，但水平前庭眼反射异常且双侧对称减弱。一年后，一名患者出现眩晕和不对称前庭眼反射。在第三年，另一名患者出现类似异常，第三名患者出现感音神经性听力损失。
我们的结果表明，胰岛素依赖型糖尿病患者可能会出现神经耳科功能恶化。
