Flisiak R
Kliniki Obserwacyjno-Zakaźnej Akademii Medycznej, Białymstoku.
Wiad Lek. 1998;51(3-4):179-85.
Knowledge related to the role of prostanoids (which include prostaglandins and prostacycline) in controlling biological phenomena in particular organs, as well as, in the whole human body, has increased gradually since the year 1930, up to now. However the role of these substances in liver functions has been developed quite recently. Experimental and clinical researches on hepatoprotective activity of prostanoids have been carried out in the last years. Mechanism of their action remains still unclear and can result from induction of hepatocytes regeneration, hepatocytes membranes stabilization, improvement of hepatic microcirculation, intracellular metabolism and respiration. In chronic liver damage it can be related to inhibition of fibrosis. These experimental observations correlate with amelioration of severe viral hepatic injury and improved prognosis after liver transplantation.
自1930年至今，有关类前列腺素（包括前列腺素和前列环素）在控制特定器官以及整个人体生物现象中所起作用的知识逐渐增多。然而，这些物质在肝脏功能中的作用直到最近才得以深入研究。近年来，已经开展了关于类前列腺素肝脏保护活性的实验和临床研究。其作用机制仍不明确，可能是由于诱导肝细胞再生、稳定肝细胞细胞膜、改善肝微循环、细胞内代谢和呼吸作用。在慢性肝损伤中，可能与抑制纤维化有关。这些实验观察结果与严重病毒性肝损伤的改善以及肝移植后预后的改善相关。
