Dalton S J, Haeney M R, Patel L, David T J
Department of Child Health, University of Manchester, Booth Hall Children's Hospital, Blackley, UK.
J R Soc Med. 1998 Mar;91(3):133-4. doi: 10.1177/014107689809100305.
In two children with atopic dermatitis, routine vaccination with bacillus Calmette-Guérin (BCG) was followed by severe exacerbation of skin disease. If the sequence is cause and effect, a possible mechanism is stimulation of a Th2 lymphocyte cytokine profile by the vaccine, with migration of activated lymphocytes to inflamed skin. In children with active atopic dermatitis, BCG vaccination is best deferred until remission.
在两名患有特应性皮炎的儿童中,常规接种卡介苗(BCG)后出现了皮肤病的严重加重。如果这种先后顺序存在因果关系,一种可能的机制是疫苗刺激了Th2淋巴细胞细胞因子谱,活化的淋巴细胞迁移至炎症皮肤。对于患有活动性特应性皮炎的儿童,最好推迟卡介苗接种直至病情缓解。