Kobliakov V A, Koliada A Iu
Vopr Med Khim. 1978 Jan-Feb;24(1):113-8.
Alteration in content of enzymatic components was studied in microsomal oxygenases system of rats administered with 2-acetyl aminofluorene. Content of cytochrome R-450 was decreased beginning from the fourth week of the experiment. Activity of NADP cytochrome c reductase was higher in animals, treated with the drug as compared with controls. Inductors of the I and II type were capable to induce the enzymatic system up to the end of the experiment - within 16 weeks as far as liver tumors developed.
对给予2-乙酰氨基芴的大鼠微粒体加氧酶系统中酶成分含量的变化进行了研究。从实验第四周开始，细胞色素R-450的含量降低。与对照组相比，用该药物处理的动物中NADP细胞色素c还原酶的活性更高。I型和II型诱导剂能够在实验结束前——长达16周，直至肝肿瘤形成——诱导酶系统。
