Beckmann M W, Mohrmann T, Jap D, Tutschek B, Bodden-Heidrich R, Dadze A G, Crombach G
Frauenklinik der Heinrich-Heine-Universität Düsseldorf.
Zentralbl Gynakol. 1998;120(6):269-74.
Osteoporosis is a systemic bone disease with a decrease in bone structure and increased risk of fractures. The primary diagnosis of osteoporosis and the surveillance of therapeutic interventions is based either on laboratory or on radiological diagnosis. In a pilot study encompassing 274 women the routine use of ultrasound osteodensitometry (QUS, Lunar Achilles) of the os calcaneus was validated and tested. Velocity of the ultrasound signal (SOS) and frequency attenuation (BUA) were measured and the proprietary index stiffness calculated. In 47 women ultrasound data were compared with the DXA measurements. Results from both methods correlated significantly. Postmenopausal patients with HRT had significant better QUS values than those without HRT. Results from both diagnostic methods (QUS versus DXA) correlated significantly. Women with HRT showed significantly increased bone measurements compared to those without HRT. This correlated with an increase in bone metabolism. QUS of the os calcaneus was easy to perform, without time spent or inconvenience for and with high acceptance by the volunteers/patients. The conformity of the results of the different methods (DXA, QUS) may--if the follow up study confirms these results--lead to a routine use of QUS for screening and therapy monitoring.
骨质疏松症是一种全身性骨骼疾病，其骨结构减少，骨折风险增加。骨质疏松症的初步诊断及治疗干预监测基于实验室诊断或放射学诊断。在一项涵盖274名女性的初步研究中，对跟骨超声骨密度测定法（定量超声，Lunar跟腱仪）的常规应用进行了验证和测试。测量了超声信号速度（SOS）和频率衰减（BUA），并计算了专有指数刚度。对47名女性的超声数据与双能X线吸收法（DXA）测量结果进行了比较。两种方法的结果显著相关。接受激素替代疗法（HRT）的绝经后患者的定量超声值明显优于未接受HRT的患者。两种诊断方法（定量超声与双能X线吸收法）的结果显著相关。与未接受HRT的女性相比，接受HRT的女性骨测量值显著增加。这与骨代谢增加相关。跟骨定量超声操作简便，志愿者/患者无需花费时间或感到不便，且接受度高。如果后续研究证实这些结果，不同方法（双能X线吸收法、定量超声）结果的一致性可能会使定量超声用于筛查和治疗监测成为常规操作。
