Würfel W, Fiedler K, von Hertwig I, Mäurer P A, Kröger K, Krüsmann G
Frauenklinik Dr. Wilhelm Krüsmann, München.
Zentralbl Gynakol. 1998;120(6):275-8.
We report on our experiences with 25 married couples that approached us for intracytoplasmatic sperm injection (ICSI) after previous failure of artificial insemination by donor (AID). AID has been carried out in several specialized fertility centers. We traditionally refrain from donor semen procedures. All patients have undergone at least 4 treatment cycles of AID, the maximum was 20. With exception of one all patients have been inseminated after ovarian hyperstimulation according to different protocols (e.g. GnRH-A/FSH, hMG; CC/hMG). Prior to ICSI we have confirmed male subfertility being in all patients of severe grade. All patients have been proven to have ejaculated spermatozoa. We have performed 71 treatment cycles for ICSI so far, 19 patients have become pregnant, 3 have aborted. The pregnancy rate per cycle is 26%, per embryo transfer 30%, and per patient 76%. We think that these results are primarily caused by so far unknown defects in oocytes and their function during fertilization. Besides, we assume psychosomatic causes maybe involved.
我们报告了25对已婚夫妇的情况，他们在之前的供体人工授精（AID）失败后前来我们这里进行卵胞浆内单精子注射（ICSI）。AID已在多个专业生育中心开展。我们传统上不进行供体精液程序。所有患者至少接受了4个周期的AID治疗，最多为20个周期。除1例外，所有患者均根据不同方案（如GnRH-A/FSH、hMG；CC/hMG）在卵巢过度刺激后进行了授精。在进行ICSI之前，我们已确认所有患者均为重度男性不育。所有患者均被证明有射精精子。到目前为止，我们已进行了71个ICSI治疗周期，19名患者怀孕，3名患者流产。每个周期的妊娠率为26%，每次胚胎移植的妊娠率为30%，每名患者的妊娠率为76%。我们认为这些结果主要是由迄今为止未知的卵母细胞缺陷及其在受精过程中的功能所致。此外，我们推测可能涉及心身原因。
