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[儿童慢性血液透析]

[Chronic hemodialysis in children].

作者信息

Delucchi A, Gutiérrez E, García de Cortázar L, Cano F, Rodríguez E, Wolff E

机构信息

Servicio de Pediatría, Hospital Gustavo Fricke, Santiago, Chile.

出版信息

Rev Med Chil. 1998 Feb;126(2):183-7.

PMID:9659754
Abstract

BACKGROUND

The final objective of every children that is admitted to a program o hemodialysis of peritoneodialysis is to receive a renal graft.

AIM

To report the experience in pediatric hemodialysis in two pediatric hospitals in Chile that are reference centers for renal transplantation.

PATIENTS AND METHODS

Sixty patients, 55% female, aged 2 to 15 years old, admitted to the dialysis and transplant program since 1987, with a creatinine clearance of less than 20 ml/min/1.73 m2, were studied.

RESULTS

Twenty percent of children were less than 5 years old at the moment of admittance to the program and 3.3% weighed less that 10 kg. Etiologies of end stage renal disease were glomerulopathies in 33.4%, reflux nephropathy in 27.7%, obstructive uropathy in 13.3%, hypoplasia/dysplasia in 10%, hereditary problems in 8.3% and vascular disorders in 5%. Eighty six percent of patients were dialyzed less than 2 years and 5% more than 4 years. Fifty percent had received prior medical treatment, 5% had been treated with intermittent peritoneal dialysis, 5% with chronic ambulatory peritoneal dialysis and 20% presented as a terminal renal failure. Sixty two percent received a renal graft, 25% is still on hemodialysis, 3.3% switched to chronic ambulatory peritoneal dialysis, 3.3% had a recovery of renal function and 6.7% died being on hemodialysis. Arterio-venous fistulae were the vascular accesses in 75% of patients, double lumen catheters in 50% and vein grafts in 5%. Malfunctioning or infections were the main complications of arterio-venous fistulae, accounting for 30% of hospital admissions.

CONCLUSIONS

The availability of new vascular accesses and new hemodialysis machines specially designed for children, along with specially trained health care personnel, should reduce the mortality and complication rates of hemodialysis in this age group.

摘要

背景

每个接受腹膜透析或血液透析治疗的儿童的最终目标都是接受肾移植。

目的

报告智利两家作为肾移植参考中心的儿科医院在儿童血液透析方面的经验。

患者与方法

对自1987年起进入透析和移植项目的60例患者进行研究,其中女性占55%,年龄在2至15岁之间,肌酐清除率低于20 ml/min/1.73 m²。

结果

20%的儿童在进入该项目时年龄小于5岁,3.3%的儿童体重低于10千克。终末期肾病的病因包括:肾小球病占33.4%,反流性肾病占27.7%,梗阻性尿路病占13.3%,发育不全/发育异常占10%,遗传性问题占8.3%,血管疾病占5%。86%的患者透析时间少于2年,5%的患者透析时间超过4年。50%的患者曾接受过前期治疗,5%的患者曾接受间歇性腹膜透析治疗,5%的患者曾接受持续性非卧床腹膜透析治疗,20%的患者以终末期肾衰竭就诊。62%的患者接受了肾移植,25%的患者仍在进行血液透析,3.3%的患者转为持续性非卧床腹膜透析,3.3%的患者肾功能恢复,6.7%的患者在血液透析期间死亡。75%的患者采用动静脉内瘘作为血管通路,50%的患者采用双腔导管,5%的患者采用静脉移植物。动静脉内瘘的主要并发症是功能障碍或感染,占住院人数的30%。

结论

新型血管通路和专门为儿童设计新型血液透析机的出现,以及经过专门培训的医护人员,应能降低该年龄组血液透析的死亡率和并发症发生率。

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