Lyness J M, Duberstein P R, King D A, Cox C, Caine E D
Department of Psychiatry, University of Rochester School of Medicine and Dentistry, NY, USA.
Am J Psychiatry. 1998 Jul;155(7):969-71. doi: 10.1176/ajp.155.7.969.
The authors tested the hypotheses that medical illness burden is independently associated with depression and that this association is moderated by neuroticism.
Multiple regression techniques were used to determine the independent associations of medical burden and neuroticism with depression in a group of 196 subjects, 60 years of age and older, recruited from primary care settings.
Medical burden and neuroticism were independently associated with major depression, depressive symptoms, and psychiatric dysfunction.
These findings support models in which medical disorders may contribute directly to depression. At the same time, the role of neuroticism in later-life depression warrants further study.
作者检验了以下假设，即医疗疾病负担与抑郁症独立相关，且这种关联受神经质的调节。
采用多元回归技术，在一组从初级保健机构招募的196名60岁及以上受试者中，确定医疗负担和神经质与抑郁症的独立关联。
医疗负担和神经质与重度抑郁症、抑郁症状及精神功能障碍独立相关。
这些发现支持了医疗疾病可能直接导致抑郁症的模型。同时，神经质在晚年抑郁症中的作用值得进一步研究。
